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Otay Mesa is a great part of San Diego to make your base. If you’re staying in Otay Mesa area then Quality Suites San Diego Otay Mesa, Holiday Inn Express & Suites San Diego Otay Mesa, and AAAmazing San Diego! Suite just for you/yours! are all recommended on KAYAK.
The average price for a hotel room in Otay Mesa is $234 but our users have found deals for as low as $230. However, hotel prices in Otay Mesa vary a lot depending on the type of hotel, the time of year and more factors.