Let KAYAK do the searching
Based on KAYAK hotel searches, the most popular destination is Cochem (50% of total searches to Mosel Valley). The next most popular destinations are Lieser (25%) and Bernkastel-Kues (25%).
KAYAK users have found double rooms in Mosel Valley for as cheap as $245 (Cochem) in the last 3 days. The average price is $417.