Experience Red Roof PLUS. Adding more WOW to your stay! Discover an enhanced experience with all new rooms and our most requested higher-end amenities. A completely remodeled and upgraded stay. The Red Roof PLUS Gainesville, Florida is 100 percent Smoke Free pet friendly, family friendly hotel. This hotel is close to I-75 at exit 384, the University of Florida, Santa Fe College, Kanapa Botanical Gardens, the Fred Bear Museum, the Performing Arts Center, Thr Florida Museum of Natrual History, Samuel Harn Museum of Art, Millhopper Devils Geological site, Hippodrome State Theatre, Gainesville Auto Plus Raceway, Oaks Mall, Butler Shopping Centers, UF Health, North Florida Regional Hospital, UF Vet Hospital and the VA Hospital.